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Hyperlipoproteinemia Type IIb, Elevated LDL VLDLsimvastatin, Zocor, Crestor, Lipitor, pravastatin, TriCor, More. While animal studies with simvastatin failed to reveal evidence of teratogenicity, animal studies with other HMG-CoA reductase inhibitors revealed an increase in the incidence of skeletal malformations. In addition, a case study has reported reversible rhabdomyolysis and acute renal failure 7 days following initiation of warfarin in a patient stabilized on simvastatin. Adverse reactions occurring with administration of either ezetimibe or simvastatin can be found in their respective monographs. MANAGEMENT: Patients receiving therapy with atorvastatin, lovastatin, simvastatin, or red yeast rice (which contains lovastatin) should be advised to avoid the regular consumption of large amounts of grapefruits and grapefruit juice (the manufacturers of simvastatin and lovastatin advise against ingestion of greater than 1 quart per day).

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